Society

Patrick Hussey

Mission Statement

"I would like my name put forward for the Chair of the Cell section. I have been working on the structure, function and regulation of the plant cytoskeleton and its potential role in biotechnology for over 25 years. During this time I have, off and on, been a member of the SEB giving my first talk as a PhD student with now Prof Iain Hagan to a crowd of 4 people including 3 supervisors and Brad Amos back in 1985 when the meeting was held at Southampton University. Either Iain or myself were not to be listened to, or the subjects were not that exciting. In those days the cytoskeleton and cell cycle were just at the beginning of their molecular and genetic investigation but they are now the embodiment of Cell Biology intercalating with studies on signalling networks that link cell growth and organism development to internal cues and environmental stimuli. The Cell Section still holds a niche for the more ‘unusual’, and maintains this niche with respect to the British Society of Cell Biology and the Cell Biology Theme Panel of the Biochemical Society, both committees of which I am a member. In such a position I can maintain the traditional values of SEB and can disseminate any good practice from these other committees. My position also offers the opportunity for any closer collaboration with the BSCB and Biochem. Soc. For example, joint Symposia or shared support within annual meetings which could potentially increase recruitment to the SEB. These collaborations will not threaten our autonomy but they will allow us to explore our own scientific portfolio and identify new areas that are not necessarily covered by these other organisations. We need to expand our membership in accordance with new themes that use new and multidisciplinary technologies and that cover aspects of Cell Biology that are up and coming because these may be the new areas that develop the field of Cell Biology."

 

Curriculum Vitae

Degrees

1980-1983         University of Liverpool. B.Sc. Hons. Biochemistry.

1983-1986         University of Kent at Canterbury and John Innes Institute, Norwich.

PhD Biology.

Employment

Postdoctoral Fellow, Department of Genetics and Cell Biology,University of Minnesota. (2/87-10/88)

Postdoctoral Fellow, John Innes Institute, Norwich. (10/88-12/89)

Lecturer, Department of Biochemistry, R.H.U.L (1/90-8/94)

Senior Lecturer, School of Biological Sciences, R.H.U.L. (9/94-4/99)

                      Professor (Chair of Plant Molecular Cell Biology), School of Biological Sciences,  R.H.U.L. (5/99-8/00)

Professor (Chair of Plant Molecular Cell Biology), School of Biological and Biomedical Sciences, University of Durham. (9/00-pres)

Current Internal and External Responsibilities

  1. Deputy Head of the School of Biological and Biomedical Sciences including Head of Research Assessment and Monitoring
  2. Member of the International Scientific Advisory Board (ISAB) for the Centre for Plant Molecular Biology ZMBP at the University of Tuebingen, Germany (2004-2010).
  3. Committee member for the Society of Experimental Biology: Cell Biology section and Group Convenor for the Cytoskeleton sub-section.
  4. Committee Member GARNET. (2008-2011)
  5. Editorial Board for Current Biology (since 2004)
  6. British Society of Cell Biology Committee member (2009-)
  7. Biochemical Society Cell Biology Theme Panel member (2009-)

Selected Papers:

  1. Piette BM, Liu J, Peeters K, Smertenko A, Hawkins T, Deeks M, Quinlan R, Zakrzewski WJ & Hussey PJ. ( 2009) A thermodynamic model of microtubule assembly and disassembly. PLoS One. Aug 11;4(8):e6378.
  2. Smertenko AP, Kaloriti D, Chang H-Y, Fiserova J, Opatrny Z &  Hussey PJ. (2008) The C-terminal variable region specifies the dynamic properties of Arabidopsis Microtubule-Associated Protein MAP65 isotypes. Plant Cell. 2008 Dec;20(12):3346-58. Epub 2008 Dec
  3. Deeks MJ, Rodrigues C, Dimmock S, Ketelaar T, Maciver SK, Malho R & Hussey PJ. (2007) Arabidopsis CAP1 a key regulator of actin organisation and development.J Cell Sci. 120, 2609-18.
  4. Salpingidou G, Smerteko A, Hausmanowa-Petrucewicz I, Hussey PJ, & Hutchison CJ. (2007) A novel role for the nuclear membrane protein emerin in association of the centrosome to the nuclear membrane. J. Cell Biol. 178(6), 897-904.
  5. Xiang Y, Huang X, Wang T, Zhang Y, Liu Q, Hussey PJ & Ren H. (2007) ACTIN BINDING PROTEIN 29 from Lilium pollen plays an important role in dynamic actin remodeling.Plant Cell. 19, 1930-1946.
  6. Uhrig J.F., Mutondo M., Zimmermann I., Deeks M.J., Machesky L.M., Thomas P., Uhrig S., Rambke C., Hussey P.J. and  Hulskamp M. (2007) The role of Arabidopsis SCAR genes in ARP2-ARP3dependent cell morphogenesis. Development 134(5) 967-977.
  7. Ketelaar T., Allwood E.G. and Hussey P.J. (2007) Actin organisation and root hair development are disrupted by ethanol induced overexpression of Arabidopsis actin interacting protein 1 (AIP1). New Phytol.174(1):57-62.
  8. Chilley P.M.,  Casson S.A., Tarkowski P., Hawkins N., Wang K.L-C., Hussey P.J., Beale M., Ecker J.R. Sandberg G.K. and Lindsey K. (2006) The POLARIS Peptide of Arabidopsis Regulates Auxin Transport and Root Growth via Effects on Ethylene Signaling. Plant Cell18(11)3058-3072.
  9. Smertenko A.P., Chang H-Y., Sonobe S., Fenyk S.I., Weingartner M., Bogre L., and Hussey P.J. (2006) Control of the AtMAP65-1 interaction with microtubules through the cell cycle. J. Cell Sci. 119(Pt 15):3227-37
  10. Lovy-Wheeler A., Kunkel J.G., Allwood E.G., Hussey P.J. and  Hepler P.K. (2006) Oscillatory increases in alkalinity anticipate growth and may regulate actin dynamics in pollen tubes of lily.Plant Cell 18(9):2182-93.
  11. Deeks M.J., and Hussey P.J. (2005) Arp2/3 and SCAR: plants move to the fore. Nature Reviews Mol Cell Biol.6 (12): 954-64.
  12. Chang H.Y., Smertenko A.P., Igarashi H., Dixon D.P., and Hussey P.J. (2005) Dynamic interaction of NtMAP65-1a with microtubules in vivo. J Cell Sci. 118 (14): 3195-201.
  13. Zheng H., Camacho L., Wee E., Batoko H., Legen J., Leaver C.J., Malho R., Hussey P.J., and Moore I. A Rab-E GTPase mutant acts downstream of the Rab-D subclass in biosynthetic membrane traffic to the plasma membrane in tobacco leaf epidermis. Plant Cell.  17(7): 2020-36.
  14. Oh SA, Johnson A, Smertenko A, Rahman D, Park SK, Hussey PJ, Twell D. (2005) A divergent cellular role for the FUSED kinase family in the plant-specific cytokinetic phragmoplast. Current Biology.15 (23): 2107-11.
  15. Deeks M.J., Cvrckova F., Machesky L.M., Mikitova V., Ketelaar T., Zarsky V., Davies B. and Hussey P.J. (2005) Arabidopsis group Ie formins localize to specific cell membrane domains, interact with actin-binding proteins and cause defects in cell expansion upon aberrant expression. New Phytol. 168 (3): 529-40.
  16. Deeks M.J., Kaloriti D., Davies B, Malho R., and Hussey P.J. (2004) Arabidopsis NAP1 is Essential for Arp2/3 Dependent Trichome Morphogenesis. Current Biology 14: 1410-1414.
  17. Ketelaar, T., Anthony, R.G. and Hussey, P.J. Green Fluorescent Protein-mTalin Causes Defects in Actin Organization and Cell Expansion in Arabidopsis and Inhibits Actin Depolymerizing Factor's Actin Depolymerizing Activity in Vitro.Plant Physiol. 2004 136(4):3990-8.
  18. Smertenko A.P., Chang H-Y., Wagner V., Kaloriti D., Fenyk S., Sonobe S., Lloyd C., Hauser M-T. and Hussey P.J. (2004) The Arabidopsis microtubule associated protein AtMAP65-1: molecular analysis of its microtubule bundling activity.Plant Cell 16 (8): 2035-2047.
  19. Muller S, Smertenko A, Wagner V, Heinrich M, Hussey PJ, Hauser MT (2004) The plant microtubule-associated protein AtMAP65-3/PLE is essential for cytokinetic phragmoplast function. Current Biology. 14 (5): 412-417.
  20. Ketelaar T, Allwood EG, Anthony R, Voigt B, Menzel D, Hussey PJ (2004) The actin-interacting protein AIP1 is essential for actin organization and plant development Current Biology 14 (2): 145149
  21. Smertenko, A.P., Bozhkov, P.V., Filonova, L.H., von Arnold, S. and Hussey, P.J. (2003) Re-organisation of the cytoskeleton during developmental programmed cell death in Picea abiesembryos. Plant J 33, 813-824
  22. Twell, D., Park, S.K., Hawkins T.J., Schubert, D., Schmidt, R., Smertenko, A.P. and Hussey, P.J. (2002) MOR1/GEM1 plays an essential role in the plant-specific cytokinetic phragmoplast. Nature Cell Biol. 4, 711-714.
  23. Allwood, E.G., Anthony, R.G., Smertenko, A.P., Reichelt, S., Drobak, B.K., Doonan, J.H., Weeds, A.G. and Hussey, P.J. (2002). Regulation of the pollen-specific actin-depolymerising factor, LlADF1. Plant Cell 14, 2915-2927.
  24. Smertenko, A.P., Allwood, E.G., Khan, S., Jiang C-J., Maciver, S.K., Weeds, A.G. and Hussey P.J. (2001)  Interaction of pollen-specific actin-depolymerising factor with actin. Plant J. 25, 203-212.
  25. Moutinho, A., Hussey, P.J., Trewavas, A.J., Malho, R. (2001) cAMP acts as a second messenger in pollen tube growth and reorientation.Proc. Natl. Acad. Sci. 98, 10481-10486.
  26. Smertenko, A.P., Saleh, N., Igarashi, H., Mori, H., Hauser-Hahn, I., Jiang, C-J., Sonobe, S., Lloyd, C.W., and Hussey, P.J. (2000) A new class of microtubule-associated proteins in plants. Nature Cell Biol. 2, 750-753.
  27. Anthony, R.G., Reichelt, S. and Hussey, P.J.(1999) Dinitroaniline herbicide resistant transgenic tobacco plants generated by co-overexpression of a mutant a -tubulin and a b -tubulin. Nature Biotech. 17, 712-716.
  28. Anthony, R.G., Waldin, T.R., Ray, J.A., Bright, S.W.J. and Hussey, P.J. (1998) Herbicide resistance caused by the spontaneous mutation of the cytoskeletal protein tubulin. Nature 393:260-263.
  29. Jiang, C-J, Weeds, A.G., Khan, S. and Hussey, P.J. (1997) F-actin and G-actin binding are uncoupled by mutation of conserved tyrosine residues in maize actin depolymerizing factor (ZmADF). Proc. Natl. Acad. Sci. 94:9973-9978.
  30. Lopez, I., R.G. Anthony, S.K. Maciver, C-J. Jiang, S. Khan, A.G. Weeds and P.J. Hussey. (1996) Pollen specific expression of maize genes encoding actin depolymerising factor-like proteins. Proc. Natl. Acad. Sci. 93: 7415-7420.

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