Cell Signalling Group convenor
Adam graduated from St Catherine’s College, Oxford, with first class honours in
biochemistry and obtained his PhD in transplantation immunology with Professor John Fabre at the Institute of Child Health, University College London. He received an EU postdoctoral fellowship to study the biochemistry of antigen presentation with Professor Jacques Neefjes at the Netherlands Cancer Institute in Amsterdam and then joined Professor Ineke Braakman’s laboratory at Utrecht University, the Netherlands, to research mechanisms of protein quality control in the endoplasmic reticulum.
Since establishing his laboratory at Durham University in 2001, Adam has been interested in both the quality control of proteins involved in antigen presentation and in the machinery that controls oxidative protein folding. In 2005, the group identified a novel member of the protein disulphide isomerase family called PDILT that has subsequently been shown to be required for sperm–egg binding and male fertility (in collaboration with Professors Masaru Okabe and Masahito Ikawa, Osaka University, Japan). This may lead to the development of new tests and cures for unexplained male infertility.
Ongoing work with the immune system seeks to explain how oxidative protein folding and ER chaperones contribute to inflammatory and autoimmune conditions. Recent studies in Adam’s laboratory have also shown that there may be a link between the oxidative protein folding machinery and gastrointestinal disease (in collaboration with clinical colleagues at James Cook University Hospital, Middlesbrough).
School of Biological and Biomedical Sciences
County Durham DH1 3LE