Bridging scales in models of cell to tissue behaviour: recent progress and future challenges

Online registration for the symposium is now closed. You are still able to register for the Chaste workshop and symposium onsite.  

Organised by: Prof Ruth Baker (University of Oxford, UK) and Dr Alexander Fletcher (University of Sheffield, UK)

Recent years have witnessed remarkable progress in molecular and live-imaging studies of cell and tissue biology, leading to large datasets that require careful interpretation. There has also been a dramatic increase in computational power. As a result, mathematical models play an ever greater role in helping us understand how subcellular phenomena, cell mechanical interactions and long-range signalling collectively give rise to tissue-level function.
To understand tissue-level function, one must be able to integrate across temporal and spatial scales in addition to understanding each scale. Modelling at each scale can require very different areas of technical skills, while integration across scales necessitates the solution to novel mathematical and computational problems.

By bringing together interdisciplinary researchers working in a variety of different application areas, this symposium aims to identify the common mathematical challenges arising in the development of ‘multiscale’ models of biological systems and accelerate progress in this area.

Immediately preceding the symposium there will be a one-day tutorial workshop on Chaste, http://www.cs.ox.ac.uk/chaste, an open-source software tool for the simulation of multicellular models.

Confirmed keynote speakers:

 

  • Dr Alexander Anderson (Moffitt Cancer Centre, United States)
    Developing eco-evolutionary cancer therapies: A multiscale approach
  • Dr Katie Bentley (Beth Israel Deaconess Medical Center, United States)
    Timing of cell movement decisions determines blood vessel network topology
  • Dr Guy Blanchard (University of Cambridge, United Kingdom)
    Inferring tissue mechanics from myosin-driven cell shape fluctuations
  • Dr Jordi Garcia-Ojalvo (Universitat Pompeu Fabra, Spain)
    Spatiotemporal regulation of metabolic activity in bacterial communities
  • Prof Henrik Jönsson (University of Cambridge, United Kingdom)
    Understanding 3D shape formation in plants - a computational morphodynamics approach
  • Prof Nancy Papalopulu (The University of Manchester, United Kingdom)
    The role of the dynamics of gene expression and stochasticity in controlling cell state transitions
  • Prof Stanislav Shvartsman (Princeton University, United States)
    Gene regulation during Drosophila eggshell patterning
  • Dr David Umulis (Purdue University, United States)
    Identification of BMP regulatory mechanisms in zebrafish and Drosophila through data integration and model-based design of experiments 
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