Improving experimental approaches in animal biology


Wednesday 29 June
Thursday 30 June
Friday 1 July

Wednesday 29 June

10:00 Registration and opening of exhibition
11:00 Welcome
Dr Lynne U Sneddon (University of Liverpool, UK)
& Dr Nic Bury (King’s College London, UK)
Session 1: Refinement
Chair: Dr Lynne U Sneddon
11:10 Dr Maja Wallberg (University of Cambridge, UK)
The use of non-invasive imaging to monitor immune responses in islets
11:40 Dr Augusto Vitale (Istituto Superiore di Sanità, Italy)
Refinement in the use of non-human primates in neuroscientific research
12:00 Dr Charlotte A Hosie (University of Chester, UK)
Refining the laboratory husbandry of the African clawed frog, Xenopus laevis
12:20  Ms Rachel J Chance (Scottish Fish Immunology Research Centre, University of Aberdeen, UK)
Developing non-lethal sampling: the effect of repeated anaesthesia on model host Atlantic salmon, Salmo salar, and model pathogen, Neoparamoeba perurans
12:35 Dr Katherine Sloman (University of the West of Scotland, UK)
Transgenerational effects of refinement in fish
13:00 Lunch/Exhibition
           Chair: Dr Lynne Sneddon
14:15 Dr Amanda CdeC Williams (University College London, UK)
Improving identification of pain
14:35 Dr Matthew Leach (Newcastle University, UK)
Pain assessment using facial expressions, what do we know?
15:05  Dr Johnny Roughan (Newcastle University, UK)
Inflammation imaging for analgesic dose rate refinement in mice
15:30 Refreshment break/Exhibition
Chair: Dr Nic Bury
16:00 Dr Lynne U Sneddon (University of Liverpool, UK)
Big brother is watching you: Automated assessment of health in fish
16:25 Miss Lauren E James (Aarhus University, Denmark)
Feeding behaviour as an indicator of pain perception in the ball python (Python regius)
16:40 Miss Catherine J A Williams (Aarhus University, Denmark)
The physiological effects of morphine in the South American rattlesnake Crotalus durissus
16:55 Pecha Kucha
17:30  End of Day 1
17:30-19:00 Poster Session

Thursday 30 June

08:30 Registration/Exhibition
  Session 2: Replacement
Chair: Dr Nic Bury
09:00 Dr Gil G Rosenthal (Texas A & M University, USA)
Artifice in animal behavior: breaking trade-offs among the 3R’s
09:25 Prof George Kemenes (University of Sussex, UK)
The use of Lymnaea stagnalis as an invertebrate model system to study amyloid-induced and age-related memory impairment  
09:50 Prof Robin S B Williams (Royal Holloway University of London, UK)
Investigating the pharmacogenetics of flavonoids using a 3Rs model
10:15 Dr Ildiko Kemenes (Sussex Neuroscience School of Life Sciences, University of Sussex, UK)
 Evolutionarily conserved mechanisms of associative learning in Lymnaea
10:30 Ms Anushika P.H.M Herath (School of Biological Sciences,
The University of Sydney, Australia)

DNA metabarcoding for noninvasive diet analysis of herbivores using Common Brushtail Possum (Trichosurus vulpecula) as a model
10:45 Ms Esther A Odekunle (Queen Mary University of London, UK)
Molecular and neuroanatomical characterization of vasopressin/oxytocin-type signalling in an echinoderm
11:00 Refreshment break/Exhibition
  Chair: Prof Craig Franklin
11:20 Dr Stefan Scholz (UFZ, Germany)
Improving the predictive capacity of the fish embryo test by analysis and quantitation of AOP-linked endpoints
11:45 Ms Melanie Knöbel (EAWAG, Switzerland)
Alternatives to animal testing in ecotoxicological risk assessment
12:10 Dr Nic Bury (King's College London, UK)
Development of an in vitro gill cell culture model to replace fish in chemical uptake studies
12:30 Dr Darren M Moss (University of Liverpool, UK)
The development of a physiologically based pharmacokinetic rat model for simulating absorption, distribution and elimination of environmental and pharmacological compounds
12:45 Ms Laura M Langan (Plymouth University, UK)
Morphological and metabolic characterization of the rainbow trout intestine grown in vitro: from pyloric to posterior  
13:00 Lunch/Exhibition
  Session 3: Reduction
Chair: Dr Nic Bury
14:00 Dr Manasi Nandi (King's College London, UK)
Animal models of sepsis and maximising data usage: a refinement and reduction case study
14:30 Prof Malcolm Macleod (University of Edinburgh, UK)
Rigour, Rigour, Rigour. practical approaches to improving the harm-benefit ratio in animal research
15:00 Dr Lewis G Halsey (University of Roehampton, UK)
Reduce with caution: small samples bring fickle P values and bloated effect sizes
15:30 Refreshments/Exhibition
  Chair: Dr Lynne Sneddon
16:00 Prof Dominic J Wells (Royal Veterinary College, UK)
Relevance is the 4th R in animal experiments
16:30  Dr Nathalie Percie du Sert (NC3Rs, UK)
NC3Rs resources to improve the design and reporting of animal research
17:00 Prof Craig E. Franklin (Chair of the Animal Section, The Society for Experimental Biology & Executive Director Research Ethics, The University of Queensland, Australia)
The universality of the 3R’s of animal ethics across a diverse and global research community
17:30 End of Day 2
19:00-late Conference Dinner

Friday 1 July

09:00  Registration/Exhibition
  Session 4: 3Rs research opportunities and resources
Chair: Dr Lynne Sneddon
09:15 Dr Mark J Prescott (NC3Rs, UK)
Pioneering better science through the 3Rs: An introduction to the NC3Rs
09:35 Ms Lydia Darragh (BBSRC, UK)
Biotechnology and Biological Sciences Research Council - BBSRC
09:55 Mrs Caroline Chadwick (LASA, UK)
What is LASA?
10:15 Ms Wendy Jarrett (Understanding Animal Research, UK)
The importance of openness about animal research
10:35 Panel discussion
10:50 Oral and poster prizes
10:55  Refreshments/Exhibition
11:10 Dr Penny Hawkins (RSPCA, UK)
Engaging with ethical review
12:40 Lunch/Exhibition
  Session 5: Educating the 3Rs
Chair: Prof John Bryant
13:30 Prof John A Bryant (University of Exeter, UK)
The Three Rs: developing an ethical framework
14:10  Dr Chris Willmott (University of Leicester, UK)
The use of multimedia in bioethics education
14:50  Prof Teresa G. Valencak (University of Veterinary Medicine, Austria)
Implementing 3R’s: transferring student learning from the classroom to lab and field
15:30  Closing comments
Dr Lynne U Sneddon (University of Liverpool, United Kingdom) and
Dr Nic Bury (King’s College London, United Kingdom)