Flower power

31 October 2016 - By: Jim Ruddock

Cold chain and virus-free chloroplast-made booster vaccine to confer immunity against different poliovirus serotypes

Plant Biotechnology Journal, Vol 86, pages 363–375, Hui-Ting Chan; Yuhong Xiao; William C. Weldon; Steven M. Oberste; Konstantin Chumakov and Henry Daniell

In this article Chan et al. address an as yet unmet urgent need in polio eradication. The WHO’s Strategic Advisory Group of Experts recommended the complete global withdrawal of oral polio vaccine (OPV) type 2 by April 2016, replacing it with inactivated poliovirus vaccine (IPV). The high cost, limited supply of IPV, persistent circulating vaccine-derived poliovirus transmission and the need for subsequent boosters remained unresolved.  In order to meet this need, the Daniell lab at the University of Pennsylvania in collaboration with the Chumakov’s laboratoru at US Food and Drug Administration developed a novel strategy using a low cost cold-chain free plant-made viral protein 1 (VP1) subunit booster vaccine, after single IPV priming.   Sera collected from immunized animals were evaluated at the US Centers for Disease Control for protection against different poliovirus serotypes.  Oral boosting with chloroplast-derived VP1 induced strong immune responses and conferred protective immunity against  all three poliovirus serotypes. Most importantly oral boosting resulted in both serum and fecal IgA titers that play a pivotal role in polio eradication because of its transmission through contaminated water or sewer systems. Lyophilized plant cells expressing VP1 maintained their efficacy indefinitely when stored at ambient temperature, eliminating cold chain requirement. Unlike significant advances in plant-made biopharmaceuticals, clinical advances in plant-made vaccines have been elusive for decades. Replacing OPV by enhancing IPV efficacy offers a unique opportunity to advance this platform to meet an urgent challenge in global infectious diseases.

Jim Ruddock, Managing Editor

Category: Plant Biology
Jim Ruddock - Author Profile

Jim Ruddock

Jim Ruddock is the Editorial Manager for The Plant Journal and Plant Biotechnology Journal, and manages all processes of each journal through the peer review system – from submission to acceptance and export of final files to the Production department. Currently at Wiley, Jim has 23 year’s of experience working in science journal publishing environments in various capacities.